Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself. Avoid drinking alcohol. It may increase your risk of liver damage. Cymbalta may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.
*seizures or epilepsy;
*a bleeding or blood clotting disorder;
*glaucoma;
*bipolar disorder (manic depression); or
*a history of drug abuse or suicidal thoughts.

You may have thoughts about suicide while taking an antidepressant, especially if you are younger than 24 years old. Tell your doctor if you have worsening depression or suicidal thoughts during the first several weeks of treatment, or whenever your dose is changed.

Your family or other caregivers should also be alert to changes in your mood or symptoms. Your doctor will need to check you at regular visits for at least the first 12 weeks of treatment.

FDA pregnancy category C. It is not known whether Cymbalta will harm an unborn baby. However, Cymbalta may cause problems in a newborn if you take the medicine during the third trimester of pregnancy. Tell your doctor if you are pregnant or plan to become pregnant while using this medication. If you are pregnant, your name may be listed on a pregnancy registry. This is to track the outcome of the pregnancy and to evaluate any effects of Cymbalta on the baby.

See also: Cymbalta pregnancy and breastfeeding warnings (in more detail)

Get emergency medical help if you have any of these signs of an allergic reaction to Cymbalta: skin rash or hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.

Call your doctor at once if you have any of these serious side effects while taking Cymbalta:

*nausea, pain in your upper stomach, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
*feeling like you might pass out;
*agitation, hallucinations, fever, fast heart rate, overactive reflexes;
*very stiff (rigid) muscles, high fever, sweating, confusion, fast or uneven heartbeats, tremors;
*easy bruising, unusual bleeding;
*painful or difficult urination;
*headache, trouble concentrating, memory problems, weakness, feeling unsteady, loss of coordination, fainting, seizure, shallow breathing or breathing that stops; or
*severe skin reaction:- fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.

Less serious Cymbalta side effects may include:

*dry mouth;
*drowsiness;
*tired feeling;
*mild nausea or loss of appetite; or
*constipation.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

See also: Cymbalta side effects (in more detail)
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